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Legendary stage and film actress Ethel Barrymore said, “You grow up the day you have your first real laugh — at yourself.” In which case, the cornucopia of celebrities who have delivered self-deprecating cameos in the spoof-happy Scary Movie Franchise — the fifth installment of which is due next month — must be among Tinseltown’s most mature denizens. We look back at some of the memorable appearances.

Scary Movie (2000)
Dawson’s Creek alum James Van Der Beek, playing himself, peeps through a bedroom window — ­interrupting a young couple’s make-out session — then declares, “Wrong set!” He won an MTV Movie Award for Best Cameo.

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Scary Movie 2 (2001)
Marlon Brando was set to play a deranged exorcist in a brief bit, but when he fell ill, Emmy winner James Woods filled his formidable shoes.

Scary Movie 3 (2003)
Jenny McCarthy, Pamela Anderson and Charlie Sheen all stop by for blink-and-you’ll-miss-’em moments, but the film’s real star cameo came in the form of an electrifying debut from the Toyota Prius, appearing for the first time in a movie, ­according to IMDb.

Scary Movie 4 (2006)
When basketball superstar and notorious free-throw choker Shaquille O’Neal is captured with feel-good guru Dr. Phil McGraw, heads roll and laughter abounds. Shaq might be Kazaam, but he just can’t sink the shot — not even when his life depends on it.

Scary Movie 5 (2013)
Mike Tyson and Ashley Tisdale are on hand to poke fun at themselves, but this installment’s big moment is a doomed lip-lock between a winning Sheen (back for more!) and Lindsay Lohan, taking deep digs at her recent public foibles.