courtesy 21c museum hotels

Many aim to seamlessly mix old with new — but few succeed. Hoteliers and contemporary art collectors Laura Lee Brown and Steve Wilson, however, have succeeded with their 21c Museum Hotels, the first of which debuted in Louisville, Ky., in 2006. The second property opened in Cincinnati this past November when the team, along with architect Deborah Berke, converted the 100-year-old former Metropole Hotel (it’s on the National Register of Historic Places) into a gorgeous boutique hotel complete with modern conveniences. In addition, the hotel has an 8,000-square-foot contemporary-art exhibition space; the Metropole restaurant, showcasing the work of the region’s sustainable farmers and producers; and the Spa at 21c, featuring RéVive skin-care products. Later this spring, a rooftop bar will be added to the mix. In this case, old is the new new. A third hotel is set to open in Bentonville, Ark., this month.

From $199,